Bibliographic References
[Management of patients with lymphatic diseases and lipoedema during the COVID-19 pandemic. Recommendations of the Spanish Group of Lymphology]
https://pubmed.ncbi.nlm.nih.gov/32863012/
PMID: 32863012
PMCID: PMC7414319
DOI: 10.1016/j.rh.2020.07.003
Pathophysiological mechanisms of thrombosis in acute and long COVID-19
https://pmc.ncbi.nlm.nih.gov/articles/PMC9709252/
PMCID: PMC9709252 PMID: 36466841
https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/
Recent Updates on COVID-19 Associated Strokes
https://pmc.ncbi.nlm.nih.gov/articles/PMC11465292/
PMCID: PMC11465292 PMID: 39391859
Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review
https://pmc.ncbi.nlm.nih.gov/articles/PMC8950504/
PMCID: PMC8950504 PMID: 33305711
COVID-19 and Cardiovascular Disease: A Comprehensive Review
https://pubmed.ncbi.nlm.nih.gov/35704865/
PMID: 35704865
COVID’s Damage Lingers in the Heart
https://magazine.hms.harvard.edu/articles/covids-damage-lingers-heart
Degradative Effect of Nattokinase on Spike Protein of SARS-CoV-2
https://pmc.ncbi.nlm.nih.gov/articles/PMC9458005/
PMCID: PMC9458005 PMID: 36080170
The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management
PMCID: PMC11384648 PMID: 39258051
2024 Aug 10;16(8):e66554. doi:10.7759/cureus.66554
The Long-Term Cardiovascular Impact of COVID-19: Pathophysiology, Clinical Manifestations, and Management - PMC
URL:https://pmc.ncbi.nlm.nih.gov/articles/PMC11384648/
https://www.sciencedirect.com/science/article/pii/S2352906724001489
I. References on Resistin and Metabolic Risk
These references support the idea that resistin is a harmful hormone linked to insulin resistance and health risks.
Resistin as a risk factor for all-cause (and cardiovascular) death in the general population
• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC9666658/
• Relevance: Confirms that resistin is a risk factor for overall and cardiovascular mortality, reinforcing its role as a "villain".
The Role of Resistin in Macrovascular and Microvascular Complications of Type 2 Diabetes
• URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC12028410/
• Relevance: Associates resistin with the development and progression of type 2 diabetes complications.
Leptin, resistin, and visfatin: the missing link between endocrine metabolic disorders and immunity
• URL: https://eurjmedres.biomedcentral.com/articles/10.1186/2047-783X-18-12
• Relevance: Confirms resistin as an adipokine linked to metabolic disorders and insulin resistance.
II. References on Mitochondrial Dysfunction and Obesity (Including Harvard)
These references support the idea that obesity causes mitochondrial dysfunction, the body's "broken engine."
Newly discovered mechanism of mitochondrial dysfunction in obesity may drive insulin resistance and type 2 diabetes
• URL: https://hsph.harvard.edu/news/newly-discovered-mechanism-of-mitochondrial-dysfunction-in-obesity-may-drive-insulin-resistance-and-type-2-diabetes/
• Relevance: Study from the Harvard T.H. Chan School of Public Health that identifies a mechanism of mitochondrial dysfunction (excessive ROS production) in obesity, providing Harvard's
authority for its narrative.
Mitochondrial Health Markers and Obesity-Related Health in Human Population Studies: A Narrative Review of Recent Literature
• URL: https://pubmed.ncbi.nlm.nih.gov/39287712/
• Relevance: Review summarizing the evidence that altered mitochondrial functions contribute to obesity.
Research | The Sinclair Lab (Harvard Medical School)
• URL: https://sinclair.hms.harvard.edu/research
• Relevance: Demonstrates that Harvard Medical School actively researches mitochondrial function and its relationship to diseases such as Type 2 Diabetes, reinforcing the credibility of its
narrative.
III. References on the Unique Mechanism (Resistin vs. Mitochondria)
These references are the most important, as they establish the direct relationship between Resistin and mitochondrial dysfunction, its "unique mechanism".
Resistin destroys mitochondrial biogenesis by inhibiting the PGC-1α/NRF1/TFAM signaling pathway
URL: https://www.sciencedirect.com/science/article/pii/S0006291X18317017
Relevance: Evidence that resistin reduces the number of mitochondria (mitochondrial biogenesis) by inhibiting the "master builder" (PGC-1α).
Resistin impairs mitochondrial homeostasis via cyclase-associated protein 1-mediated fission, leading to obesity-induced metabolic diseases
URL: https://www.sciencedirect.com/science/article/pii/S0026049522002219
Relevance: Evidence that resistin breaks down and fragments mitochondria (abnormal fission), making them dysfunctional.
IV. Additional Reference (Context)
Leukocyte mitochondrial DNA copy number, anthropometric indices, and weight change in US women
URL: https://pubmed.ncbi.nlm.nih.gov/27367031/
Newly detected diabetes during the COVID-19 pandemic: what have we learnt?
Newly detected diabetes during the COVID-19 pandemic: what have we learnt? - PMC
10.1016/j.beem.2023.101793
PMCID: PMC10303323 PMID: 37468405
The enduring effect of the COVID-19 pandemic on diabetes
https://www.thelancet.com/journals/landia/article/PIIS2213-8587(24)00180-3/fulltext
A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on
https://pmc.ncbi.nlm.nih.gov/articles/PMC9107388/
10.1016/j.metabol.2022.155217
PMCID: PMC9107388 PMID: 35584732